Xavier vs. Pittsburgh 2010 NCAA Bracket Predictions, Odds & Picks: Xavier will try to prove that they are more than just a feisty squad that can make it past the first round of the tournament when they play Pittsburgh at 5 PM ET. Xavier (25-8) has made it to the second round of the tournament four years in a row and is coming off a 65-54 win over Minnesota as -1.5 favorites. Pittsburgh (25-8) took a moment to get going against Oakland but once they did, they dominated in an 89-66 win as -9.5 favorites. Below is a winning March madness picks play to make some serious green with.