San Francisco 49ers vs. Seattle Seahawks Week 13 NFL Picks: Two struggling NFC West teams that are out of the playoff race will face off this Sunday at 4:15 PM ET when the Seahawks host the 49ers. San Fran (5-6) lives and dies with their defense and last week they lived with a 20-3 win over Jacksonville as -3 home favorites. Seattle (4-7) labored through a 27-17 win over St. Louis last week as -3.5 away favorite.
 

Seattle Offense vs. San Francisco Defense: Seattle’s #20 offense squares off against the 49ers #11 defense. Seattle has become a run-first team all of a sudden with rookie RB Justin Forsett (5’8” 185 4.60 40-speed) having consecutive 100-yard rushing games. San Fran is stingy against the run ranking 5th in yards allowed so this match-up is even.  Through the air San Fran is susceptible to the big-play which gives Seattle QB Matt Hasselbeck (1955 yds, 11-7 ratio, 81.0) a slight edge. Slight edge Seattle. The San Francisco 49ers vs. Seattle Seahawks Week 13 NFL Picks NFL Betting Odds Total is at 41.5 points.

San Francisco Offense vs. Seattle Defense: San Francisco’s #19 offense will face the Seahawks #20 defense. The 49ers have been using a lot of shotgun formations with new QB Alex Smith (1267 yds, 11-7 ratio, 84.7 passer rating) but those could be rendered  useless by the crowd noise at Quest Field. Seattle’s pass-defense is mediocre and the 49ers O-line shoved Seattle’s smaller defenders around in their first meeting. San Fran All-Pro RB Frank Gore (877 yds, 5.0 ypc, 9 td-1 fum) should have a big day against a Seahawks run D that has allowed 131.7 yards per game in their last three games. Slight advantage San Fran.
 
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Intangibles: San Fran is 7-2-3 ATS in their last 12 games. Seattle is 7-2-1 ATS in their last 12 games. San Fran is 0-6 when they score 16 points or less. San Fran is 5-0 when they score more than 16 points. San Francisco has the edge on special teams.