2010 Week 1 NFL Predictions: The AFC South division will feature a high-powered week 1 slugfest when the Houston Texans hosts bitter rival Indianapolis at 1 PM ET. The Colts are still smarting from their Superbowl loss to the Saints but with all of their core players intact they are poised for another fine season. After a solid 9-7 season the Texans appear to be finally gaining ground on the Colts and could have their best campaign in franchise history. Below is a winning free sports picks play on this fine opening week match-up from our NFL picks team of experts.

2010 Week 1 NFL Predictions Analysis: The Houston Texans are not afraid of the big, bad Indianapolis Colts and you can bet that every Texans player and coach has the opener circled with an exclamation point. Conference games are always important but beating the Colts means everything to Houston. The Texans always give Indy a tough outing and this season they are really coming into their own. The Indianapolis Colts vs. Houston Texans NFL Odds TOTAL is at 47.0 points.

Houston has an explosive offense that is tough to keep off the field and that essentially is the blueprint to beating Indianapolis. The Texans defense is tough against both the run and pass and will have a nice edge on special teams. Play on the heart and desire factor for Houston to cover as home underdogs.

2010 Week 1 NFL Prdictions: Houston Texans +2.5 NFL Odds