USC vs Arizona St. Week 10 College Football Picks: This Saturday 12th ranked USC will try to put last week’s miserable loss to Oregon behind them and get a win against Arizona State on the road at 8 PM ET Saturday. USC (6-2) was beaten in every aspect of the game in last week’s 20-47 loss to Oregon as -3 away favorites. Arizona State (4-4) came up just short in a conference game against California last week 21-23 as +5 home underdogs.
 
The USC vs Arizona St. Week 10 College Football Picks NCAA Football betting spread is USC -10 at Sportsbook.com.

Analysis: USC coach Pete Carroll has been very dismissive of the Oregon loss but getting outgained by 286 yards in a game they were suppose to win is eye opening. Arizona St. has traditionally played USC tough and Carroll better have his team prepared to not suffer a letdown.USC freshmen QB Matt Barkley (9-6 ratio, 59.3%) has played well most of the season and Arizona St. head coach Dennis Erickson had this to say about the young signal-caller: "He's a talent and one of the better young guys around. He's young and got a great arm, great release, he has tremendous composure. He's got an aura about him that all of the good quarterbacks have." Barkley along with 6’0 200 Lb. RB Joe McKnight (838 ttl yds, 6.4, 7 td) and #1 WR Damian Williams (43 rec, 607 yds, 4 td) give USC some explosive weapons on offense.
 
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Arizona St.’s QB Danny Sullivan has also played well this season (8-7 ratio, 54.4%) but Arizona’s State’s offense will be at a disadvantage (#38-#70). Arizona St. leads the Pac-10 in run defense and their pass defense is at the slimmest disadvantage to USC’s (#16-#17). Overall on defense Arizona St. holds the slight edge (#25-#27). Arizona St. also holds the edge on special teams (#36-#45). The USC vs Arizona St. Week 10 College Football Picks NCAA Football betting Total is at 46.0 points.
 
Intangibles: USC is 2-6 ATS. Arizona St. is 4-3-1 ATS. USC is 1-7 ATS in their last 8 road games. Arizona St. has lost 9 straight to USC. Arizona St. has lost 17 straight games to top-15 teams. Arizona St. has a +4 point home-field advantage.