Chargers vs 49ers Odds 2010 NFL Preseason Week 4: The San Francisco 49ers (3-0) host the San Diego Chargers (1-2) in the last game of the 2010 NFL Betting Preseason. San Diego opens up their first season without Ladanian Tomlinson against their division rival Kansas City Chiefs. The Niners open up their regular season against the Seattle Seahawks. Both teams are expected to play their first-team offenses and defenses deep into the second half. Hammerhead Sports always delivers the most accurate free sports picks and football odds from our team of NFL Predictions experts. Find our Winning NFL Picks selections below.

The Niners put together a 16-play, 80-yard drive to win it last week against Oakland. The biggest play might have been Carr's 5-yard run on third-and-3. Frank Gore ran for 58 yards on two carries in his first action of the preseason for the Niners, Alex Smith threw a touchdown pass to Josh Morgan and rookie Phillip Adams scored on an 83-yard punt return as San Francisco remained undefeated in the preseason. The defense has looked especially ready for the season. The books at SBG Global have the San Francisco 49ers (-3) as the Free NFL Picks selection over the San Diego Chargers (+3).

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Philip Rivers led two touchdown drives for the Chargers (1-2). His 167 yards passing included a 9-yard TD toss to Malcom Floyd. Antonio Gates caught five passes for 66 yards. Antoine Cason a 2008 first-round draft pick, can help fill the void left when the Chargers traded Antonio Cromartie to the New York Jets. Cason had a rough night against Brees and the Saints' high-powered offense, though.He was victimized on New Orleans' second score when he anticipated a throw to the corner of the end zone, only to have Meachem cut underneath for an easy 15-yard touchdown catch. With the NFL Betting Odds point total at 36.5. the Under(-110) seems like the strong choice here.