2010 CWS Odds: South Carolina Gamecocks at Clemson Tigers Picks & Predictions: With its 6-4 win over #6 Oklahoma on Wednesday, #8 Clemson (45-23) stayed unbeaten in the College World Series and will face #5 South Carolina (50-16) (Friday 9:00 PM ET on ESPN2). The Tigers, who are 2-0 in the College World Series, need to beat the Gamecocks once to advance to the Championship Series.  If South Carolina tops the Tigers on Friday, the two teams will play a decisive game on Saturday at 7:00 PM EDT on ESPN to determine the winner of the bracket.  Clemson will be the designated home team and occupy the third-base dugout on Friday. Hammerhead Sports always offers the most accurate free 2010 College World Series picks from our team of 2010 College World Series predictions experts. Find our winning College World Series Picks below. 

Earlier in 2010, the Tigers won two of the three games, including a 4-3 win at Clemson on March 5 and a 19-6 win in Columbia on March 7.  On March 6 at Fluor Field in Greenville, SC, South Carolina rallied late to defeat the Tigers 7-5.  The rivalry moved to the three-game format (with games at each team's home stadium and a neutral-site game) for the first time in 2010. Jack Leggett is 32-30 against South Carolina as Clemson's head coach, including 0-3 in neutral-site games and 0-2 in NCAA Tournament games.  Both losses were in the 2002 College World Series when the two teams were in the exact same situation as they are in 2010.  Leggett was also 3-8 against the Gamecocks as Western Carolina's head coach, meaning he is 35-38 all-time against South Carolina.

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In game-one at Doug Kingsmore Stadium in Clemson on March 5, Wilson Boyd's two-out, run-scoring single in the eighth inning lifted the Tigers to a 4-3 victory over South Carolina. In game-two at Fluor Field in Greenville, SC on March 6, Whit Merrifield's two-out, run-scoring single in the top of the ninth inning gave South Carolina the lead for good in its 7-5 win over Clemson. In game-three at Carolina Stadium in Columbia, SC on March 7, Clemson hit five home runs to trounce South Carolina 19-6. 

It was the most runs scored by Clemson against the Gamecocks since 1962 and the Tigers' largest margin of victory in the series since 1997. Sportsbook.com College World Series Betting Odds have the Clemson Tigers (-130) as a home favorite against the South Carolina Gamecocks (+125). Look for clemson to end South Carolina's Cahampionship run.